Aim. To demonstrate the role of treatment timing on the outcomes of dentofacial orthopedics for treatment of Class II dentoskeletal disharmony. Materials and methods. A controlled clinical trial on the results of Twin Block therapy of Class II patients and a very recent meta-analysis of the studies on functional jaw orthopedics revealed the significant role of timing of treatment on treatment modifications. Results and conclusions. The results of methodologically-sound cephalometric studies of both the past and the recent history of orthodontics clearly indicate that optimal treatment timing for Class II skeletal disharmony with a functional appliance (e.g. Twin Block) is during or slightly after the peak in mandibular growth as revealed by a reliable biologic indicator of individual skeletal maturity such as the cervical vertebral maturation method.
(Rev Esp Ortod. 2011;41(4):199-204)